2011 Family Circle Cup – Singles

In 2011, world number-one Caroline Wozniacki defeated Elena Vesnina in the final 6–2, 6–3 to win the women's singles tennis title at that year's Charleston Open. Samantha Stosur was the defending champion, but lost to Vesnina in the third round.

Seeds
The top eight seeds received a bye into the second round. • # Caroline Wozniacki (champion)

• # 🇦🇺 Samantha Stosur (third round)

• # 🇷🇸 Jelena Janković (semifinals)

• # 🇫🇷 Marion Bartoli (second round)

• # 🇮🇱 Shahar Pe'er (third round)

• # 🇧🇪 Yanina Wickmayer (quarterfinals)

• # 🇷🇺 Nadia Petrova (third round)

• # 🇷🇺 Alisa Kleybanova (second round)

• # 🇷🇺 Maria Kirilenko (second round)

• # 🇸🇰 Daniela Hantuchová (third round)

• # 🇨🇳 Peng Shuai (semifinals)

• # 🇩🇪 Julia Görges (quarterfinals)

• # Patty Schnyder (first round)

• # 🇺🇸 Bethanie Mattek-Sands (second round)

• # 🇨🇿 Barbora Záhlavová-Strýcová (third round)

• # 🇷🇺 Vera Dushevina (first round)

Seeds
• # 🇺🇸 CoCo Vandeweghe (qualifying competition)

• # 🇮🇳 Sania Mirza (qualified)

• # 🇯🇵 Junri Namigata (first round)

• # 🇬🇧 Heather Watson (qualified)

• # Anna Tatishvili (qualified)

• # 🇺🇸 Irina Falconi (qualified)

• # 🇨🇿 Eva Birnerová (qualified)

• # 🇩🇪 Tatjana Malek (qualifying competition)

• # 🇺🇦 Olga Savchuk(qualifying competition)

• # 🇫🇷 Stéphanie Foretz Gacon (qualifying competition)

• # 🇺🇸 Madison Brengle (first round)

• # 🇺🇸 Lindsay Lee-Waters (first round)

• # 🇺🇸 Sloane Stephens (qualified)

• # 🇺🇦 Tetiana Luzhanska (qualifying competition)

• # 🇸🇰 Lenka Wienerová (qualifying competition)

• # 🇷🇺 Ekaterina Bychkova (qualifying competition)

Qualifiers
• # 🇺🇸 Alexandra Stevenson

• # 🇮🇳 Sania Mirza

• # 🇺🇸 Sloane Stephens

• # 🇬🇧 Heather Watson

• # Anna Tatishvili

• # 🇺🇸 Irina Falconi

• # 🇨🇿 Eva Birnerová

• # Monica Puig