2011 Fifth Third Bank Tennis Championships – Women's singles

Kurumi Nara was the defending champion, but chose not to participate. Chichi Scholl won the final against Amanda Fink 6–1, 6–1.

Seeds
• # 🇺🇸 Melanie Oudin (first round)

• # 🇺🇸 Alison Riske (quarterfinals)

• # 🇺🇸 Sloane Stephens (first round)

• # 🇺🇦 Tetiana Luzhanska (quarterfinals)

• # 🇺🇸 Julia Cohen (first round)

• # 🇭🇺 Melinda Czink (first round)

• # 🇨🇦 Heidi El Tabakh (second round)

• # 🇭🇰 Zhang Ling (semifinals)