2011 Italian Open – Women's singles

Maria Sharapova defeated Samantha Stosur in the final, 6–2, 6–4 to win the women's singles tennis title at the 2011 Italian Open. It was her 23rd career title, and her first in almost a year.

María José Martínez Sánchez was the defending champion, but lost in the first round to Ekaterina Makarova.

Seeds
The top eight seeds receive a bye into the second round. • # Caroline Wozniacki (semifinals)

• # 🇮🇹 Francesca Schiavone (quarterfinals)

• # 🇧🇾 Victoria Azarenka (quarterfinals, retired due to a right elbow contusion)

• # 🇨🇳 Li Na (semifinals)

• # 🇷🇸 Jelena Janković (quarterfinals)

• # 🇦🇺 Samantha Stosur (final)

• # 🇷🇺 Maria Sharapova (champion)

• # 🇵🇱 Agnieszka Radwańska (second round)

• # 🇫🇷 Marion Bartoli (second round)

• # 🇮🇱 Shahar Pe'er (third round)

• # 🇷🇺 Svetlana Kuznetsova (first round)

• # 🇩🇪 Andrea Petkovic (second round)

• # 🇷🇸 Ana Ivanovic (second round)

• # 🇪🇪 Kaia Kanepi (first round)

• # 🇮🇹 Flavia Pennetta (first round)

• # 🇷🇺 Anastasia Pavlyuchenkova (third round)