2011 Knoxville Challenger – Singles

Kei Nishikori was the defending champion but decided not to participate. Jesse Levine won the title, defeating Brian Baker 6–2, 6–3 in the final.

Seeds
• # 🇺🇸 Michael Russell (quarterfinals)

• # 🇺🇸 Bobby Reynolds (first round)

• # Rik de Voest (second round)

• # Izak van der Merwe (second round)

• # 🇨🇦 Vasek Pospisil (quarterfinals)

• # 🇧🇾 Uladzimir Ignatik (quarterfinals)

• # 🇺🇸 Michael Yani (second round)

• # 🇦🇺 Greg Jones (first round)