2011 Prime Cup Aberto de São Paulo – Singles

In the singles matches of the 2011 Prime Cup Aberto de São Paulo, 1st seed Ricardo Mello successfully defended his last year's title after defeating qualifier Rafael Camilo 6–2, 6–1 in the final. It was Mello's fourth overall and third consecutive win in São Paulo.

Seeds
• # 🇧🇷 Ricardo Mello (champion)

• # 🇦🇷 Horacio Zeballos (second round)

• # 🇧🇷 João Souza (quarterfinals)

• # 🇦🇷 Máximo González (first round)

• # 🇧🇷 Thiago Alves (first round)

• # 🇧🇷 Rogério Dutra da Silva (second round)

• # 🇦🇷 Federico del Bonis (semifinals)

• # Paul Capdeville (first round)