2011 Regions Morgan Keegan Championships – Singles

Sam Querrey was the defending champion, but lost to Mardy Fish in the quarterfinals.

Andy Roddick won his third title at this event, and the 30th of his career, defeating Milos Raonic 7–6(9–7), 6–7(11–13), 7–5 in the final. Roddick made a diving forehand to break serve for the match on his fifth championship point. Roddick stated: "That's the best shot I've ever hit in my life, considering the circumstance."

Seeds
• # 🇺🇸 Andy Roddick (champion)

• # 🇪🇸 Fernando Verdasco (first round)

• # 🇫🇷 Gaël Monfils (withdrew due to a wrist injury)

• # 🇺🇸 Mardy Fish (semifinals)

• # 🇺🇸 Sam Querrey (quarterfinals)

• # 🇺🇸 John Isner (first round)

• # Lu Yen-hsun (first round)

• # Kevin Anderson (first round)

• # 🇧🇪 Xavier Malisse (first round, retired)