2011 Winston-Salem Open – Singles

Sergiy Stakhovsky was the defending champion, but lost to Julien Benneteau in the quarterfinals. John Isner defeated Benneteau in the final, 4–6, 6–3, 6–4.

Seeds
All seeds received a bye into the second round. • # 🇺🇸 Andy Roddick (semifinals)

• # 🇦🇹 Jürgen Melzer (second round)

• # 🇺🇦 Alexandr Dolgopolov (quarterfinals)

• # 🇺🇸 John Isner (champion)

• # 🇷🇺 Nikolay Davydenko (third round)

• # Kevin Anderson (withdrew due to illness)

• # 🇦🇷 Juan Mónaco (quarterfinals)

• # 🇨🇾 Marcos Baghdatis (quarterfinals)

• # 🇺🇦 Sergiy Stakhovsky (quarterfinals)

• # Robin Haase (semifinals)

• # 🇷🇺 Dmitry Tursunov (second round)

• # 🇪🇸 Pablo Andújar (second round)

• # 🇫🇮 Jarkko Nieminen (third round)

• # 🇧🇬 Grigor Dimitrov (third round)

• # 🇨🇴 Santiago Giraldo (third round)

• # 🇷🇺 Igor Kunitsyn (second round)