2012 Brisbane International – Men's singles

Robin Söderling was the defending champion, but decided not to participate this year. Andy Murray, who made his debut appearance at the tournament, beat Alexandr Dolgopolov 6–1, 6–3 to take the title.

Seeds
• # 🇬🇧 Andy Murray (champion)

• # 🇫🇷 Gilles Simon (semifinals)

• # 🇺🇦 Alexandr Dolgopolov (final)

• # 🇩🇪 Florian Mayer (first round, retired due to a right groin injury)

• # 🇯🇵 Kei Nishikori (second round)

• # 🇨🇿 Radek Štěpánek (quarterfinals)

• # 🇦🇹 Jürgen Melzer (first round)

• # 🇦🇺 Bernard Tomic (semifinals)

Seeds
• # 🇩🇪 Tobias Kamke (qualifying competition)

• # 🇷🇺 Igor Andreev (qualified)

• # 🇯🇵 Tatsuma Ito (qualified)

• # 🇱🇹 Ričardas Berankis (first round)

• # 🇺🇸 Bobby Reynolds (first round)

• # 🇪🇪 Jürgen Zopp (qualifying competition)

• # 🇩🇪 Simon Greul (first round)

• # 🇺🇸 Jesse Levine (qualified)

Qualifiers
• # 🇺🇸 Jesse Levine

• # 🇷🇺 Igor Andreev

• # 🇯🇵 Tatsuma Ito

• # 🇦🇺 John Millman