2012 CNGvitall Prague Open – Singles

The men's singles of the 2012 CNGvitall Prague Open tournament was played on clay in Prague, Czech Republic.

Lukáš Rosol was the defending champion but lost in the quarterfinals. Horacio Zeballos won the title 1–6, 6–4, 7–6(8–6) in the final against Martin Kližan.

Seeds
• # 🇮🇱 Dudi Sela (second round)

• # 🇸🇰 Lukáš Lacko (first round)

• # 🇨🇿 Lukáš Rosol (quarterfinals)

• # 🇩🇪 Tobias Kamke (semifinals)

• # 🇧🇬 Grigor Dimitrov (second round)

• # 🇸🇰 Martin Kližan (final)

• # 🇩🇪 Matthias Bachinger (quarterfinals)

• # 🇩🇪 Daniel Brands (first round)