2012 Campeonato Internacional de Tenis de Santos – Singles

João Souza is the defending champion, but lost in the first round to Facundo Argüello. Ivo Minář won the title by defeating Ricardo Hocevar 4–6, 6–1, 6–4 in the final.

Seeds
• # 🇧🇷 João Souza (first round)

• # Blaž Kavčič (first round)

• # Paul Capdeville (first round)

• # 🇦🇷 Diego Junqueira (quarterfinals)

• # 🇧🇷 Rogério Dutra da Silva (quarterfinals)

• # 🇧🇷 Ricardo Mello (first round)

• # 🇧🇷 Thiago Alves (first round)

• # 🇦🇷 Máximo González (quarterfinals)