2012 Charlottesville Men's Pro Challenger – Singles

Izak van der Merwe was defending champion but defeated in the semifinals by Denis Kudla. Kudla went on to win the title after defeating Alex Kuznetsov 6–0, 6–3 in the final.

Seeds
• # 🇺🇸 Jesse Levine (first round)

• # 🇷🇺 Alex Bogomolov Jr. (semifinals)

• # 🇺🇸 Michael Russell (withdrew)

• # 🇩🇪 Mischa Zverev (first round)

• # 🇺🇸 Ryan Sweeting (first round)

• # 🇺🇸 Bobby Reynolds (second round)

• # 🇺🇸 Tim Smyczek (second round)

• # 🇺🇸 Denis Kudla (champion)