2012 Fifth Third Bank Tennis Championships – Men's singles

Wayne Odesnik was the defending champion but decided not to participate. Denis Kudla won the title, defeating Érik Chvojka 5–7, 7–5, 6–1 in the final.

Seeds
• # 🇧🇪 Maxime Authom (first round)

• # 🇩🇴 Víctor Estrella (first round)

• # 🇫🇷 Adrian Mannarino (first round)

• # 🇺🇸 Denis Kudla (champion)

• # 🇬🇧 Jamie Baker (second round)

• # 🇦🇷 Agustín Velotti (quarterfinals)

• # 🇦🇺 James Duckworth (quarterfinals)

• # 🇨🇦 Érik Chvojka (final)