2012 John Newcombe Women's Pro Challenge – Singles

This was a new event in 2012. Melanie Oudin won the title, defeating Mariana Duque in the final, 6–1, 6–1.

Seeds
• # 🇮🇹 Camila Giorgi (quarterfinals)

• # 🇺🇸 Lauren Davis (first round)

• # 🇺🇸 Melanie Oudin (champion)

• # Mirjana Lučić (semifinals)

• # Michelle Larcher de Brito (quarterfinals)

• # 🇨🇴 Mariana Duque (final)

• # 🇺🇸 Madison Keys (semifinals)

• # 🇺🇸 Chichi Scholl (second round)