2012 Natomas Men's Professional Tennis Tournament – Singles

Ivo Karlović was the defending champion but decided not to participate. James Blake won the title, defeating Mischa Zverev 6–1, 1–6, 6–4 in the final.

Seeds
• # 🇩🇪 Benjamin Becker (first round)

• # 🇺🇸 James Blake (champion)

• # 🇺🇸 Ryan Sweeting (withdrew because of food poisoning)

• # 🇺🇸 Wayne Odesnik (first round)

• # 🇮🇹 Matteo Viola (quarterfinals)

• # 🇨🇦 Peter Polansky (first round, retired because of a shoulder injury)

• # 🇺🇸 Tim Smyczek (first round)

• # 🇺🇸 Denis Kudla (first round)