2012 São Léo Open – Singles

Leonardo Mayer was the defending champion but decided not to participate. Horacio Zeballos defeated Paul Capdeville 3–6, 7–5, 7–6(7–2) in the final.

Seeds
• # 🇦🇹 Andreas Haider-Maurer (second round)

• # 🇸🇮 Blaž Kavčič (semifinals)

• # 🇦🇷 Horacio Zeballos (champion)

• # 🇧🇷 Rogério Dutra da Silva (quarterfinals)

• # Gastão Elias (quarterfinals)

• # 🇧🇷 João Souza (first round)

• # Antonio Veić (second round)

• # Paul Capdeville (final)