2012 Southern Miss Golden Eagles football team

The 2012 Southern Miss Golden Eagles football team represented the University of Southern Mississippi in the 2012 NCAA Division I FBS football season as a member of the East Division of Conference USA. They were led by first-year head coach Ellis Johnson and played their home games at M. M. Roberts Stadium in Hattiesburg, Mississippi. The 2012 squad finished the season winless with a final record of 0–12 and after only one year at the helm, Johnson along with his entire staff was fired.

Louisville
Last meeting was in the 2010 Beef 'O' Brady's Bowl.