2012 US Open – Girls' singles

Grace Min was the defending champion, having won the event in 2011, but did not compete.

Wildcard Samantha Crawford defeated twelfth seed Anett Kontaveit in the final 7–5, 6–3, to win her first junior grand slam title.

Seeds
• # 🇺🇸 Taylor Townsend (quarterfinals)

• # 🇰🇿 Yulia Putintseva (quarterfinals; withdrew)

• # 🇨🇦 Eugenie Bouchard (second round)

• # 🇩🇪 Antonia Lottner (semifinals)

• # 🇷🇺 Elizaveta Kulichkova (first round)

• # 🇨🇿 Kateřina Siniaková (third round)

• # 🇸🇰 Petra Uberalová (first round)

• # 🇺🇸 Sachia Vickery (third round)

• # 🇰🇿 Anna Danilina (quarterfinals)

• # 🇺🇸 Chalena Scholl (second round)

• # Belinda Bencic (second round)

• # 🇪🇪 Anett Kontaveit (final)

• # Ana Konjuh (third round)

• # 🇨🇦 Carol Zhao (third round)

• # 🇺🇸 Krista Hardebeck (first round)

• # 🇲🇽 Marcela Zacarías (third round)

Qualifiers
• # 🇺🇸 Nicole Frenkel

• # 🇲🇽 Victoria Rodríguez

• # 🇺🇸 Tornado Alicia Black

• # 🇺🇸 Rasheeda McAdoo

• # 🇺🇸 Louisa Chirico

• # Madrie Le Roux

• # 🇭🇺 Szabina Szlavikovics

• # 🇨🇦 Marika Akkerman