2012 Uruguay Open – Singles

Carlos Berlocq was the defending champion but decided not to participate. Horacio Zeballos won the title, defeating Julian Reister 6–3, 6–2 in the final.

Seeds
• # João Sousa (second round)

• # 🇦🇹 Andreas Haider-Maurer (first round)

• # 🇫🇷 Guillaume Rufin (withdrew)

• # 🇸🇮 Blaž Kavčič (second round)

• # 🇦🇷 Guido Pella (first round)

• # 🇷🇴 Adrian Ungur (semifinals)

• # 🇦🇷 Horacio Zeballos (champion)

• # Thiemo de Bakker (first round)