2013 Italian Open – Women's singles

Serena Williams defeated Victoria Azarenka in the final, 6–1, 6–3 to win the women's singles tennis title at the 2013 Italian Open. It was her second Internazionali BNL d'Italia title, and she won it without dropping a set, without dropping more than three games per set, and without dropping more than four games per match.

Maria Sharapova was the two-time defending champion, but withdrew in the quarterfinals against Sara Errani due to illness.

Seeds
The top eight seeds receive a bye into the second round. • # 🇺🇸 Serena Williams (champion)

• # 🇷🇺 Maria Sharapova (quarterfinals, withdrew because of illness)

• # 🇧🇾 Victoria Azarenka (final)

• # 🇵🇱 Agnieszka Radwańska (second round)

• # 🇨🇳 Li Na (third round)

• # 🇩🇪 Angelique Kerber (withdrew because of an abdominal injury)

• # 🇮🇹 Sara Errani (semifinals)

• # 🇨🇿 Petra Kvitová (third round)

• # 🇦🇺 Samantha Stosur (quarterfinals)

• # Caroline Wozniacki (first round)

• # 🇷🇺 Nadia Petrova (first round)

• # 🇷🇺 Maria Kirilenko (third round, retired)

• # 🇮🇹 Roberta Vinci (third round)

• # 🇸🇰 Dominika Cibulková (third round)

• # 🇷🇸 Ana Ivanovic (first round)

• # 🇺🇸 Sloane Stephens (third round)

Seeds
• # 🇪🇸 Lourdes Domínguez Lino (qualifying competition, lucky loser)

• # Stefanie Vögele (first round)

• # Chanelle Scheepers (first round)

• # 🇧🇾 Olga Govortsova (first round)

• # 🇺🇸 Madison Keys (qualifying competition)

• # 🇪🇸 Anabel Medina Garrigues (qualified)

• # 🇷🇴 Simona Halep (qualified)

• # 🇪🇸 Sílvia Soler Espinosa (qualifying competition)

• # 🇺🇸 Lauren Davis (qualifying competition)

• # 🇺🇸 Jamie Hampton (qualifying competition)

• # 🇸🇰 Daniela Hantuchová (qualifying competition)

• # 🇺🇦 Lesia Tsurenko (qualified)

• # 🇨🇿 Andrea Hlaváčková (qualified)

• # Anna Tatishvili (first round)

• # 🇺🇸 Mallory Burdette (qualified)

• # 🇪🇸 Garbiñe Muguruza (qualified)

Qualifiers
• # 🇨🇿 Andrea Hlaváčková

• # 🇺🇦 Lesia Tsurenko

• # 🇺🇸 Melanie Oudin

• # 🇫🇷 Mathilde Johansson

• # 🇺🇸 Mallory Burdette

• # 🇪🇸 Anabel Medina Garrigues

• # 🇷🇴 Simona Halep

• # 🇪🇸 Garbiñe Muguruza

Lucky losers

 * 1) 🇪🇸 Lourdes Domínguez Lino