2013 Mutua Madrid Open – Men's singles

Rafael Nadal defeated Stan Wawrinka in the final, 6–2, 6–4 to win the men's singles tennis title at the 2013 Madrid Open.

Roger Federer was the defending champion, but lost to Kei Nishikori in the third round. This edition of the Madrid Open was the first since 2001 (when the tournament was held in Stuttgart) to not feature either of the top two seeds in the quarterfinals, as world No. 1 Novak Djokovic was defeated in the second round by Grigor Dimitrov.

Seeds
The top eight seeds receive a bye into the second round. • # 🇷🇸 Novak Djokovic (second round)

• # Roger Federer (third round)

• # 🇬🇧 Andy Murray (quarterfinals)

• # 🇪🇸 David Ferrer (quarterfinals)

• # 🇪🇸 Rafael Nadal (champion)

• # 🇨🇿 Tomáš Berdych (semifinals)

• # 🇫🇷 Jo-Wilfried Tsonga (quarterfinals)

• # 🇫🇷 Richard Gasquet (second round)

• # 🇷🇸 Janko Tipsarević (first round)

• # Marin Čilić (first round)

• # 🇪🇸 Nicolás Almagro (second round)

• # 🇨🇦 Milos Raonic (second round)

• # 🇩🇪 Tommy Haas (third round)

• # 🇯🇵 Kei Nishikori (quarterfinals)

• # Stan Wawrinka (final)

• # 🇫🇷 Gilles Simon (third round)

Seeds
• # 🇦🇺 Marinko Matosevic (qualifying competition, lucky loser)

• # 🇧🇪 Xavier Malisse (qualified)

• # 🇫🇷 Michaël Llodra (qualifying competition)

• # 🇦🇷 Carlos Berlocq (first round)

• # 🇨🇴 Alejandro Falla (first round)

• # 🇪🇸 Guillermo García López (qualified)

• # Igor Sijsling (qualifying competition)

• # Robin Haase (qualified)

• # 🇫🇷 Paul-Henri Mathieu (qualifying competition, retired)

• # 🇩🇪 Tobias Kamke (qualified)

• # 🇷🇺 Evgeny Donskoy (first round)

• # 🇨🇴 Santiago Giraldo (qualified)

• # 🇫🇷 Guillaume Rufin (first round)

• # 🇨🇦 Jesse Levine (qualified)

Qualifiers
• # 🇩🇪 Tobias Kamke

• # 🇧🇪 Xavier Malisse

• # Robin Haase

• # 🇨🇴 Santiago Giraldo

• # 🇧🇷 João Souza

• # 🇪🇸 Guillermo García López

• # 🇨🇦 Jesse Levine

Lucky loser

 * 1) 🇦🇺 Marinko Matosevic