2013 Winston-Salem Open – Singles

John Isner was the two-time defending champion, but withdrew from the tournament because of a hip injury. Jürgen Melzer won the title, defeating Gaël Monfils in the final, 6–3, 2–1, ret.

Seeds
All seeds received a bye into the second round. • # 🇨🇿 Tomáš Berdych (withdrew because of a right shoulder injury)

• # 🇮🇹 Andreas Seppi (second round)

• # 🇺🇸 John Isner (withdrew because of a hip injury)

• # 🇪🇸 Tommy Robredo (third round)

• # 🇫🇷 Benoît Paire (third round)

• # 🇺🇸 Sam Querrey (semifinals)

• # 🇪🇸 Fernando Verdasco (quarterfinals)

• # 🇦🇷 Juan Mónaco (third round)

• # 🇦🇹 Jürgen Melzer (champion)

• # 🇺🇦 Alexandr Dolgopolov (semifinals)

• # 🇫🇮 Jarkko Nieminen (third round)

• # 🇨🇿 Lukáš Rosol (second round)

• # 🇷🇺 Dmitry Tursunov (quarterfinals)

• # 🇸🇰 Martin Kližan (second round)

• # 🇫🇷 Gaël Monfils (final, retired because of a left hip injury)

• # 🇪🇸 Pablo Andújar (second round)

Seeds
• # 🇧🇪 David Goffin (qualified)

• # João Sousa (qualifying competition, lucky loser)

• # Thiemo de Bakker (qualified)

• # 🇺🇸 Denis Kudla (qualifying competition, lucky loser)

• # 🇺🇸 Steve Johnson (qualified)

• # 🇦🇺 James Duckworth (second round)

• # 🇮🇳 Saketh Myneni (second round)

• # 🇮🇳 Sanam Singh (qualifying competition)

Qualifiers
• # 🇧🇪 David Goffin

• # 🇺🇸 Steve Johnson

• # Thiemo de Bakker

• # Frederik Nielsen

Lucky losers
• # João Sousa

• # 🇺🇸 Denis Kudla