2014 US Open – Women's singles

Two-time defending champion Serena Williams defeated Caroline Wozniacki in the final, 6–3, 6–3 to win the women's singles tennis title at the 2014 US Open. It was her Open Era-record-equaling sixth US Open singles title and 18th major singles title overall, equaling Martina Navratilova and Chris Evert's tally. She did not lose a set during the tournament for a record-equaling third time, and did not lose more than three games in any set. This was the first leg in her second 'Serena Slam', a non-calendar year Grand Slam.

The top three seeds (Williams, Simona Halep and Petra Kvitová) were in contention for the world No. 1 ranking. Williams retained the top position after Halep and Kvitová lost in the third round.

This was the first major main draw appearance for CiCi Bellis, who at the age of 15 became the youngest player to win a match at the US Open since 1996.

Seeds
• 🇺🇸 Serena Williams (champion)

• 🇷🇴 Simona Halep (third round)

• 🇨🇿 Petra Kvitová (third round)

• 🇵🇱 Agnieszka Radwańska (second round)

• 🇷🇺 Maria Sharapova (fourth round)

• 🇩🇪 Angelique Kerber (third round)

• 🇨🇦 Eugenie Bouchard (fourth round)

• 🇷🇸 Ana Ivanovic (second round)

• 🇷🇸 Jelena Janković (fourth round)

• Caroline Wozniacki (final)

• 🇮🇹 Flavia Pennetta (quarterfinals)

• 🇸🇰 Dominika Cibulková (first round)

• 🇮🇹 Sara Errani (quarterfinals)

• 🇨🇿 Lucie Šafářová (fourth round)

• 🇪🇸 Carla Suárez Navarro (third round)

• 🇧🇾 Victoria Azarenka (quarterfinals)

• 🇷🇺 Ekaterina Makarova (semifinals)

• 🇩🇪 Andrea Petkovic (third round)

• 🇺🇸 Venus Williams (third round)

• 🇷🇺 Svetlana Kuznetsova (first round)

• 🇺🇸 Sloane Stephens (second round)

• 🇫🇷 Alizé Cornet (third round)

• 🇷🇺 Anastasia Pavlyuchenkova (second round)

• 🇦🇺 Samantha Stosur (second round)

• 🇪🇸 Garbiñe Muguruza (first round)

• 🇩🇪 Sabine Lisicki (third round)

• 🇺🇸 Madison Keys (second round)

• 🇮🇹 Roberta Vinci (third round)

• 🇦🇺 Casey Dellacqua (fourth round)

• 🇨🇿 Barbora Záhlavová-Strýcová (third round)

• 🇯🇵 Kurumi Nara (second round)

• 🇨🇳 Zhang Shuai (first round)