2015–16 Cypriot Second Division

The 2015–16 Cypriot Second Division was the 61st season of the Cypriot second-level football league. It began on 18 September 2015 and ended on 26 March 2016. Karmiotissa won their first title.

Team changes from 2014–15
Teams promoted to 2015–16 Cypriot First Division
 * Enosis Neon Paralimni
 * Pafos FC
 * Aris Limassol

Teams relegated from 2014–15 Cypriot First Division
 * Othellos Athienou

Teams promoted from 2014–15 Cypriot Third Division
 * THOI Lakatamia
 * ASIL Lysi
 * PAEEK

Teams relegated to 2015–16 Cypriot Third Division
 * APEP

Stadia and locations

 * Note: Table lists clubs in alphabetical order.