2015–16 Southern Illinois Salukis women's basketball team

The 2015–16 Southern Illinois women's basketball team represents Southern Illinois University Carbondale during the 2015–16 NCAA Division I women's basketball season. The Salukis, led by third year head coach Cindy Stein. They played their home games at SIU Arena and were members of the Missouri Valley Conference. They finished the season 20–13, 12–6 in MVC play to finish in fourth place. They advanced to the semifinals of the Missouri Valley women's tournament where they lost to Southern Illinois. They were invited to the Women's Basketball Invitational where they lost to Western Illinois in the first round.

Schedule
!colspan=9 style="background:#800000; color:white;"| Exhibition

!colspan=9 style="background:#800000; color:white;"| Non-conference regular season

!colspan=9 style="background:#800000; color:white;"| Missouri Valley regular season

!colspan=9 style="background:#800000; color:white;"| Missouri Valley Women's Tournament

!colspan=9 style="background:#800000; color:white;"| WBI