2015 Italian Open – Men's singles

Defending champion Novak Djokovic defeated Roger Federer in the final, 6–4, 6–3 to win the men's singles tennis title at the 2015 Italian Open. It was Djokovic's fourth Italian Open title, the second-most of all-time behind Rafael Nadal. This is notable for being the only clay court final contested between Djokovic and Federer. It was Federer's fourth runner-up finish at the Italian Open (following defeats to Félix Mantilla in 2003 and to Nadal in 2006 and 2013), and his career-best finish at the event.

Seeds
The top eight seeds receive a bye into the second round. • 🇷🇸 Novak Djokovic (champion)

• Roger Federer (final)

• 🇬🇧 Andy Murray (third round, withdrew because of fatigue)

• 🇪🇸 Rafael Nadal (quarterfinals)

• 🇯🇵 Kei Nishikori (quarterfinals)

• 🇨🇿 Tomáš Berdych (quarterfinals)

• 🇪🇸 David Ferrer (semifinals)

• Stan Wawrinka (semifinals)

• Marin Čilić (first round)

• 🇧🇬 Grigor Dimitrov (second round)

• 🇪🇸 Feliciano López (second round)

• 🇫🇷 Gilles Simon (second round, retired because of a neck injury)

• 🇫🇷 Jo-Wilfried Tsonga (second round)

• 🇪🇸 Roberto Bautista Agut (second round)

• Kevin Anderson (third round)

• 🇺🇸 John Isner (third round)

Seeds
• # Borna Ćorić (qualifying competition)

• # 🇰🇿 Mikhail Kukushkin (first round)

• # 🇦🇷 Diego Schwartzman (qualified)

• # 🇪🇸 Pablo Carreño Busta (first round)

• # 🇪🇸 Daniel Gimeno Traver (first round)

• # 🇺🇿 Denis Istomin (first round)

• # 🇦🇷 Federico Delbonis (qualifying competition)

• # 🇫🇷 Benoît Paire (qualifying competition)

• # 🇺🇦 Alexandr Dolgopolov (qualified)

• # 🇷🇸 Dušan Lajović (qualified)

• # Blaž Kavčič (first round, retired)

• # 🇧🇷 Thomaz Bellucci (qualified)

• # 🇧🇷 João Souza (first round)

• # 🇦🇹 Jürgen Melzer (first round)

Qualifiers
• # 🇷🇸 Dušan Lajović

• # 🇮🇹 Andrea Arnaboldi

• # 🇦🇷 Diego Schwartzman

• # 🇮🇹 Thomas Fabbiano

• # 🇹🇷 Marsel İlhan

• # 🇧🇷 Thomaz Bellucci

• # 🇺🇦 Alexandr Dolgopolov