2015 Regional League Division 2 North Eastern Region

 Regional League Division 2 North Eastern Region is the 7th season of the League competition since its establishment in 2009. It is in the third tier of the Thai football league system. The league winners and runners up qualified for the 2015 Regional League Division 2 champions league round.

Promoted clubs
No club was promoted to the Thai Division 1 League. Last years league champions Ubon Ratchathani, runners up Udon Thani failed to qualify from the 2014 Regional League Division 2 champions league round.

Relegated clubs
Khonkaen and Roi Et United were relegated from the 2014 Thai Division 1 League.

Renamed clubs

 * Nong Bua Lamphu renamed Nong Bua Pitchaya.
 * Ubon UMT F.C. renamed Ubon Ratchathani F.C.
 * Mukdahan City renamed Mukdahan Lamkhong.
 * Mahasarakham United renamed Mahasarakham.
 * Loei City renamed Loei City R-Airlines.

Expansion clubs
Khon Kaen United and Ubon UMT United joined the newly expanded league setup.