2015 San Luis Open Challenger Tour – Singles

Paolo Lorenzi was the defending champion, but lost in the semifinals.

Guido Pella won the title, defeating James McGee in the final, 6–3, 6–3.

Seeds
• # 🇷🇺 Teymuraz Gabashvili (quarterfinals)

• # 🇮🇹 Paolo Lorenzi (semifinals)

• # 🇧🇦 Damir Džumhur (first round)

• # 🇦🇺 James Duckworth (semifinals)

• # 🇮🇹 Luca Vanni (withdrew)

• # 🇪🇸 Adrián Menéndez Maceiras (quarterfinals)

• # 🇺🇸 Austin Krajicek (second round)

• # 🇦🇷 Horacio Zeballos (first round)