2016 Abierto Mexicano Telcel – Men's singles

David Ferrer was the defending champion, but lost to Alexandr Dolgopolov in the second round.

Dominic Thiem won the title, defeating Bernard Tomic in the final, 7–6(8–6), 4–6, 6–3.

Seeds
• #🇪🇸 David Ferrer (second round)

• #🇯🇵 Kei Nishikori (second round)

• # Marin Čilić (first round)

• #🇦🇹 Dominic Thiem (champion)

• #🇦🇺 Bernard Tomic (final)

• # Ivo Karlović (first round, retired)

• #🇧🇬 Grigor Dimitrov (quarterfinals)

• #🇫🇷 Jérémy Chardy (first round)

Seeds
• # Thiemo de Bakker (qualified)

• # 🇺🇸 Taylor Fritz (qualified)

• # 🇲🇩 Radu Albot (first round)

• # 🇺🇸 Ryan Harrison (qualified)

• # 🇦🇺 John-Patrick Smith (qualifying competition)

• # 🇺🇸 Dennis Novikov (first round)

• # 🇪🇸 Adrián Menéndez-Maceiras (qualifying competition)

• # 🇺🇸 Alexander Sarkissian (qualifying competition)

Qualifiers
• # Thiemo de Bakker

• # 🇺🇸 Taylor Fritz

• # 🇺🇸 Tommy Paul

• # 🇺🇸 Ryan Harrison