2016 Barcelona Open Banc Sabadell – Singles

Rafael Nadal defeated the two-time defending champion Kei Nishikori in the final, 6–4, 7–5 to win the singles title at the 2016 Barcelona Open. It was Nadal's record-extending ninth title at the Barcelona Open and his 49th clay court title, equaling Guillermo Vilas' record for the most titles on clay.

Seeds
All seeds receive a bye into the second round. • 🇪🇸 Rafael Nadal (champion)

• 🇯🇵 Kei Nishikori (final)

• 🇪🇸 David Ferrer (withdrew because of a calf injury)

• 🇫🇷 Richard Gasquet (withdrew because of a back injury)

• 🇪🇸 Roberto Bautista Agut (second round)

• 🇫🇷 Benoît Paire (semifinals)

• 🇪🇸 Feliciano López (third round)

• 🇷🇸 Viktor Troicki (third round)

• Pablo Cuevas (third round)

• 🇩🇪 Philipp Kohlschreiber (semifinals)

• 🇺🇦 Alexandr Dolgopolov (quarterfinals)

• 🇮🇹 Fabio Fognini (quarterfinals)

• 🇫🇷 Jérémy Chardy (third round)

• João Sousa (second round)

• 🇧🇷 Thomaz Bellucci (second round)

• 🇷🇺 Andrey Kuznetsov (quarterfinals)

Seeds
• # 🇩🇪 Jan-Lennard Struff (qualified)

• # 🇷🇺 Karen Khachanov (qualified)

• # 🇸🇰 Jozef Kovalík (first round)

• # 🇹🇷 Marsel İlhan (first round)

• # 🇫🇷 Kenny de Schepper (first round)

• # Franko Škugor (qualified)

• # 🇦🇷 Renzo Olivo (qualifying competition, lucky loser)

• # 🇷🇺 Andrey Rublev (first round)

• # 🇨🇿 Radek Štěpánek (qualified)

• # 🇷🇸 Peđa Krstin (qualifying competition)

• # 🇫🇷 Édouard Roger-Vasselin (qualifying competition, lucky loser)

• # 🇦🇷 Marco Trungelliti (qualifying competition)

Qualifiers
• # 🇩🇪 Jan-Lennard Struff

• # 🇷🇺 Karen Khachanov

• # 🇦🇷 Pedro Cachin

• # 🇭🇺 Márton Fucsovics

• # 🇨🇿 Radek Štěpánek

• # Franko Škugor

Lucky losers
• # 🇦🇷 Renzo Olivo

• # 🇫🇷 Édouard Roger-Vasselin