2016 Brisbane International – Men's singles

Roger Federer was the defending champion, but lost in the final to Milos Raonic, 4–6, 4–6.

Seeds
The top four seeds receive a bye into the second round. • # Roger Federer (final)

• # 🇯🇵 Kei Nishikori (quarterfinals)

• # Marin Čilić   (quarterfinals)

• # 🇨🇦 Milos Raonic (champion)

• # 🇫🇷 Gilles Simon (first round)

• # 🇧🇪 David Goffin (second round)

• # 🇦🇺 Bernard Tomic (semifinals)

• # 🇦🇹 Dominic Thiem (semifinals)

Seeds
• # Ernests Gulbis (qualifying competition)

• # Ivan Dodig (qualified)

• # Thiemo de Bakker (first round)

• # 🇺🇸 Tim Smyczek (qualifying competition)

• # 🇯🇵 Yoshihito Nishioka (qualified)

• # 🇺🇸 Jared Donaldson (qualifying competition)

• # 🇸🇰 Norbert Gombos (first round)

• # 🇺🇸 Dennis Novikov (first round)

Qualifiers
• # 🇯🇵 Yoshihito Nishioka

• # Ivan Dodig

• # 🇩🇪 Tobias Kamke

• # 🇦🇺 Oliver Anderson