2016 Brisbane International – Women's singles

Maria Sharapova was the defending champion, but withdrew before her first match due to a wrist injury.

Victoria Azarenka won her first title in almost 3 years, beating Angelique Kerber in the final, 6–3, 6–1.

Seeds
The top two seeds receive a bye into the second round. • # 🇷🇴 Simona Halep (withdrew due to a leg injury)

• # 🇪🇸 Garbiñe Muguruza (second round, retired due to a left foot injury)

• # 🇷🇺 Maria Sharapova (withdrew due to a wrist injury)

• # 🇩🇪 Angelique Kerber (final)

• # Timea Bacsinszky (first round)

• # 🇪🇸 Carla Suárez Navarro (semifinals)

• # Belinda Bencic (second round)

• # 🇮🇹 Roberta Vinci (quarterfinals)

Seeds
• # 🇧🇬 Tsvetana Pironkova (first round)

• # 🇷🇺 Margarita Gasparyan (qualifying competition, lucky loser)

• # 🇸🇰 Daniela Hantuchová (first round)

• # 🇺🇦 Kateryna Bondarenko (qualified)

• # 🇧🇾 Aliaksandra Sasnovich (first round)

• # 🇧🇬 Sesil Karatantcheva (first round)

• # 🇷🇺 Elena Vesnina (qualified)

• # 🇫🇷 Pauline Parmentier (first round)

Qualifiers
• # 🇺🇸 Samantha Crawford

• # 🇸🇰 Jana Čepelová

• # 🇷🇺 Elena Vesnina

• # 🇺🇦 Kateryna Bondarenko

Lucky losers
• # 🇷🇺 Margarita Gasparyan

• # 🇧🇪 Ysaline Bonaventure