2016 Campeonato Internacional de Tenis de Santos – Singles

Blaž Rola was the defending champion but chose not to defend his title.

Renzo Olivo won the title after defeating Thiago Monteiro 6–4, 7–6(7–5) in the final.

Seeds
• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇧🇷 Thiago Monteiro (final)

• # 🇧🇷 Rogério Dutra Silva (quarterfinals)

• # 🇦🇷 Renzo Olivo (champion)

• # 🇧🇷 João Souza (first round)

• # 🇦🇷 Guido Andreozzi (quarterfinals)

• # 🇦🇷 Nicolás Kicker (quarterfinals)

• # 🇦🇷 Máximo González (semifinals)