2016 Città di Caltanissetta – Singles

Elias Ymer was the defending champion but lost in the second round to Alessandro Giannessi.

Paolo Lorenzi won the title after defeating Matteo Donati 6–3, 4–6, 7–6(9–7) in the final.

Seeds
• # 🇮🇹 Paolo Lorenzi (champion)

• # 🇦🇷 Facundo Bagnis (second round)

• # 🇸🇪 Elias Ymer (second round)

• # Thiemo de Bakker (first round)

• # 🇨🇴 Santiago Giraldo (second round)

• # 🇨🇴 Alejandro González (first round)

• # 🇪🇸 Daniel Gimeno Traver (first round)

• # 🇷🇸 Peđa Krstin (first round)