2016 Claro Open Medellín – Men's singles

Paolo Lorenzi was the defending champion but chose not to defend his title.

Facundo Bagnis won the title after defeating Caio Zampieri 6–7(3–7), 7–5, 6–2 in the final.

Seeds
• # 🇩🇴 Víctor Estrella Burgos (first round)

• # 🇦🇷 Facundo Bagnis (champion)

• # 🇧🇷 Rogério Dutra Silva (semifinals)

• # 🇦🇷 Renzo Olivo (second round)

• # 🇧🇷 João Souza (semifinals)

• # 🇨🇴 Santiago Giraldo (quarterfinals)

• # 🇦🇷 Nicolás Kicker (second round)

• # 🇨🇴 Alejandro González (second round)