2016 Copa Libertadores second stage

The 2016 Copa Libertadores second stage was played from 16 February to 21 April 2016. A total of 32 teams competed in the second stage to decide the 16 places in the final stages of the 2016 Copa Libertadores.

Draw
The draw of the tournament was held on 22 December 2015, 20:30 PYST (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.

Starting from this season, teams were seeded by the newly established CONMEBOL ranking of the Copa Libertadores (except for teams from Mexico which were not ranked and thus seeded last in all draws), taking into account of the following three factors: The six winners of the first stage which joined the 26 direct entrants were as follows:
 * 1) Performance in the last 10 years, taking into account Copa Libertadores results in the period 2006–2015
 * 2) Historical coefficient, taking into account Copa Libertadores results in the period 1960–2005
 * 3) Local tournament champion, with bonus points awarded to domestic league champions of the last 10 years
 * Winner G1: 🇨🇴 Santa Fe
 * Winner G2: 🇦🇷 Huracán
 * Winner G3: 🇦🇷 Racing
 * Winner G4: River Plate
 * Winner G5: 🇪🇨 Independiente del Valle
 * Winner G6: 🇧🇷 São Paulo

Groups
The fixture list was determined by the draw as follows:
 * Round 1: Team 3 vs. Team 1, Team 4 vs. Team 2
 * Round 2: Team 1 vs. Team 4, Team 2 vs. Team 3
 * Round 3: Team 2 vs. Team 1, Team 3 vs. Team 4
 * Round 4: Team 1 vs. Team 2, Team 4 vs. Team 3
 * Round 5: Team 4 vs. Team 1, Team 3 vs. Team 2
 * Round 6: Team 1 vs. Team 3, Team 2 vs. Team 4

The matches were played on 16–18, 23–25 February, 1–3, 8–10, 15–17 March, 5–7, 12–14 and 19–21 April 2016.