2016 Delray Beach International Tennis Championships – Singles

Ivo Karlović was the defending champion, but lost to John-Patrick Smith in the first round.

Sam Querrey won the title, defeating Rajeev Ram in the final, 6–4, 7–6(8–6).

The tournament marked the return of Juan Martín del Potro after suffered from wrist injury.

Seeds
• # Kevin Anderson (first round, retired)

• #🇦🇺 Bernard Tomic (first round)

• # Ivo Karlović (first round)

• #🇧🇬 Grigor Dimitrov (semifinals)

• #🇫🇷 Jérémy Chardy (quarterfinals)

• #🇺🇸 Steve Johnson (second round)

• #🇺🇸 Donald Young (second round)

• #🇫🇷 Adrian Mannarino (quarterfinals)

Seeds
• # 🇮🇹 Luca Vanni (qualifying competition)

• # 🇯🇵 Tatsuma Ito (qualified)

• # 🇲🇩 Radu Albot (qualified)

• # 🇨🇴 Alejandro Falla (qualifying competition)

• # 🇯🇵 Yoshihito Nishioka (qualifying competition)

• # 🇺🇸 Bjorn Fratangelo (qualifying competition)

• # 🇦🇺 John-Patrick Smith (qualified)

• # 🇺🇸 Dennis Novikov (qualified)

Qualifiers
• # 🇺🇸 Dennis Novikov

• # 🇯🇵 Tatsuma Ito

• # 🇲🇩 Radu Albot

• # 🇦🇺 John-Patrick Smith