2016 Fergana Challenger – Men's singles

Teymuraz Gabashvili was the defending champion, but decided not to defend his title.

Radu Albot won the title after defeating Konstantin Kravchuk 6–4, 6–2 in the final.

Seeds
• # 🇷🇺 Konstantin Kravchuk (final)

• # 🇲🇩 Radu Albot (champion)

• # 🇷🇺 Alexander Kudryavtsev (quarterfinals, retired)

• # 🇰🇿 Dmitry Popko (quarterfinals)

• # 🇰🇷 Lee Duck-hee (semifinals)

• # 🇺🇦 Denys Molchanov (first round, retired)

• # 🇷🇸 Nikola Milojević (semifinals)

• # 🇧🇾 Ilya Ivashka (quarterfinals)