2016 Illinois State Redbirds football team

The 2016 Illinois State Redbirds football team represented Illinois State University as a member of the Missouri Valley Football Conference (MVFC) during the 2016 NCAA Division I FCS football season. Led by eighth-year head coach Brock Spack, the Redbirds compiled an overall record of 6–6 with a mark of 4–4 in conference play, tying for fourth place the MVFC. For the third straight season, Illinois State received an at-large bid to the NCAA Division I Football Championship playoffs, where the Redbirds lost in the first round to Central Arkansas. The team played home games at Hancock Stadium in Normal, Illinois.

@ Northwestern
The Redbirds beat the Wildcats 9–7. The win came on an Illinois State field goal as time expired. This was ISU's first-ever victory over a Big Ten team.