2016 Internazionali di Tennis Castel del Monte – Singles

Ivan Dodig was the defending champion but chose not to defend his title.

Luca Vanni won the title after defeating Matteo Berrettini 5–7, 6–0, 6–3 in the final.

Seeds
• # 🇺🇦 Sergiy Stakhovsky (semifinals)

• # Marco Chiudinelli (second round)

• # Stefanos Tsitsipas (quarterfinals)

• # 🇮🇹 Luca Vanni (champion)

• # 🇧🇦 Aldin Šetkić (quarterfinals)

• # 🇯🇵 Akira Santillan (second round)

• # 🇮🇳 Ramkumar Ramanathan (first round)

• # 🇪🇸 Adrián Menéndez-Maceiras (first round)