2016 Internazionali di Tennis Città di Vicenza – Singles

Íñigo Cervantes was the defending champion, but chose not to defend his title.

Guido Andreozzi won the title when Pere Riba retired in the final.

Seeds
• # Gastão Elias (semifinals)

• # 🇩🇪 Daniel Brands (second round)

• # 🇧🇷 Thiago Monteiro (first round)

• # 🇨🇴 Alejandro González (second round)

• # 🇦🇷 Renzo Olivo (first round)

• # 🇦🇷 Nicolás Kicker (quarterfinals)

• # 🇮🇹 Luca Vanni (second round)

• # 🇪🇸 Daniel Gimeno-Traver (quarterfinals)