2016 Italian Open – Men's singles

Andy Murray defeated the two-time defending champion Novak Djokovic in the final, 6–3, 6–3 to win the men's singles tennis title at the 2016 Italian Open.

This was the first Italian Open in 11 years which was not won by either of Rafael Nadal or Djokovic.

Seeds
The top eight seeds receive a bye into the second round. • 🇷🇸 Novak Djokovic (final)

• 🇬🇧 Andy Murray (champion)

• Roger Federer (third round)

• Stan Wawrinka (third round)

• 🇪🇸 Rafael Nadal (quarterfinals)

• 🇯🇵 Kei Nishikori (semifinals)

• 🇫🇷 Jo-Wilfried Tsonga (withdrew due to muscle strain)

• 🇨🇿 Tomáš Berdych (third round)

• 🇪🇸 David Ferrer (third round)

• 🇨🇦 Milos Raonic (second round)

• 🇫🇷 Richard Gasquet (third round)

• 🇧🇪 David Goffin (quarterfinals)

• 🇦🇹 Dominic Thiem (quarterfinals)

• 🇫🇷 Gaël Monfils (first round)

• 🇪🇸 Roberto Bautista Agut (second round)

• Kevin Anderson (second round)

Seeds
• # 🇫🇷 Lucas Pouille (qualifying competition, lucky loser)

• # 🇬🇧 Aljaž Bedene (qualified)

• # 🇫🇷 Paul-Henri Mathieu (first round)

• # 🇺🇸 Denis Kudla (qualifying competition)

• # 🇹🇳 Malek Jaziri (first round, retired)

• # Robin Haase (qualifying competition)

• # 🇪🇸 Íñigo Cervantes (qualified)

• # 🇷🇸 Dušan Lajović (first round)

• # 🇺🇸 Taylor Fritz (first round)

• # 🇧🇦 Damir Džumhur (qualified)

• # 🇺🇸 Rajeev Ram (qualifying competition)

• # Ernests Gulbis (qualified)

• # 🇰🇿 Mikhail Kukushkin (qualified)

• # 🇩🇪 Benjamin Becker (withdrew)

Qualifiers
• # 🇰🇿 Mikhail Kukushkin

• # 🇬🇧 Aljaž Bedene

• # 🇫🇷 Stéphane Robert

• # Ernests Gulbis

• # 🇮🇹 Filippo Volandri

• # 🇧🇦 Damir Džumhur

• # 🇪🇸 Íñigo Cervantes

Lucky losers
• # 🇫🇷 Lucas Pouille