2016 Las Vegas Challenger – Singles

Thiemo de Bakker was the defending champion but chose not to defend his title.

Sam Groth won the title after defeating Santiago Giraldo 6–7(4–7), 6–4, 7–5 in the final.

Seeds
• # 🇩🇴 Víctor Estrella Burgos (first round)

• # 🇺🇸 Frances Tiafoe (first round)

• # 🇺🇸 Bjorn Fratangelo (second round)

• # 🇨🇴 Santiago Giraldo (final)

• # Darian King (second round)

• # 🇺🇸 Denis Kudla (first round)

• # 🇺🇸 Dennis Novikov (second round)

• # 🇦🇷 Marco Trungelliti (semifinals)