2016 McNeese State Cowboys football team

The 2016 McNeese State Cowboys football team represented McNeese State University as a member of the Southland Conference during the 2016 NCAA Division I FCS football season. Led by first-year head coach Lance Guidry, the Cowboys compiled an overall record of 6–5 with a mark of 5–4 in conference play, tying for fourth place in the Southland. McNeese State played home games at Cowboy Stadium in Lake Charles, Louisiana.

Tarleton State
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@ Louisiana–Lafayette
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Stephen F. Austin
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@ Incarnate Word
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Nicholls State
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@ Southeastern Louisiana
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Central Arkansas
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@ Northwestern State
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Abilene Christian
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@ Sam Houston State
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Lamar
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