2016 Miami Open – Men's singles

Two-time defending champion Novak Djokovic defeated Kei Nishikori in the final, 6–3, 6–3 to win the men's singles tennis title at the 2016 Miami Open. Djokovic completed his record fourth Sunshine Double with the win, and won his record-equaling sixth Miami Open title. It was also his third consecutive Sunshine Double. He did not lose a single set in the entire tournament.

For the first time in tournament history, no Americans reached the last-of-16 stage.

Seeds
All seeds receive a bye into the second round. • 🇷🇸 Novak Djokovic (champion)

• 🇬🇧 Andy Murray (third round)

• Roger Federer (withdrew because of stomach virus)

•  Stan Wawrinka (second round)

• 🇪🇸 Rafael Nadal (second round, retired due to illness)

• 🇯🇵 Kei Nishikori (final)

• 🇨🇿 Tomáš Berdych (quarterfinals)

• 🇪🇸 David Ferrer (third round)

• 🇫🇷 Jo-Wilfried Tsonga (third round)

• 🇫🇷 Richard Gasquet (fourth round)

•  Marin Čilić (third round)

• 🇨🇦 Milos Raonic (quarterfinals)

• 🇺🇸 John Isner (second round)

• 🇦🇹 Dominic Thiem (fourth round)

• 🇧🇪 David Goffin (semifinals)

• 🇫🇷 Gaël Monfils (quarterfinals)

• 🇪🇸 Roberto Bautista Agut (fourth round)

• 🇫🇷 Gilles Simon (quarterfinals)

• 🇷🇸 Viktor Troicki (third round)

• 🇫🇷 Benoît Paire (third round)

• 🇪🇸 Feliciano López (second round)

• 🇺🇸 Jack Sock (third round)

•  Pablo Cuevas (third round)

• 🇦🇺 Nick Kyrgios (semifinals)

•  🇸🇰 Martin Kližan (withdrew)

• 🇧🇬 Grigor Dimitrov (fourth round)

• 🇺🇦 Alexandr Dolgopolov (third round)

• 🇫🇷 Jérémy Chardy (second round)

• 🇺🇸 Sam Querrey (second round)

• 🇧🇷 Thomaz Bellucci (second round, retired)

• 🇺🇸 Steve Johnson (third round)

• 🇪🇸 Guillermo García López (second round)

•  João Sousa (third round)

Seeds
• # 🇺🇸 Taylor Fritz (qualified)

• # 🇰🇿 Mikhail Kukushkin (qualified)

• # 🇪🇸 Marcel Granollers (qualified)

• # 🇯🇵 Yūichi Sugita (first round)

• # 🇺🇸 Austin Krajicek (first round)

• # 🇩🇪 Benjamin Becker (qualified)

• # 🇹🇳 Malek Jaziri (first round)

• # 🇫🇷 Pierre-Hugues Herbert (qualified)

• # 🇦🇷 Horacio Zeballos (qualifying competition, lucky loser)

• # 🇧🇷 Rogério Dutra Silva (qualifying competition, lucky loser)

• # 🇺🇸 Tim Smyczek (qualified)

• # 🇯🇵 Tatsuma Ito (qualified)

• # 🇯🇵 Yoshihito Nishioka (qualified)

• # 🇦🇺 John-Patrick Smith (first round)

• # 🇨🇴 Alejandro Falla (first round)

• # 🇩🇪 Daniel Brands (first round)

• # 🇧🇦 Mirza Bašić (first round)

• # 🇫🇷 Édouard Roger-Vasselin (first round)

• # 🇧🇪 Ruben Bemelmans (first round)

• # 🇫🇷 Kenny de Schepper (first round)

• # 🇦🇷 Facundo Argüello (first round)

• # 🇮🇹 Luca Vanni (first round)

• # 🇨🇴 Alejandro González (qualified)

• # 🇦🇷 Carlos Berlocq (first round)

Qualifiers
• # 🇺🇸 Taylor Fritz

• # 🇰🇿 Mikhail Kukushkin

• # 🇪🇸 Marcel Granollers

• # 🇺🇸 Bjorn Fratangelo

• # 🇺🇸 Dennis Novikov

• # 🇩🇪 Benjamin Becker

• # 🇨🇴 Alejandro González

• # 🇫🇷 Pierre-Hugues Herbert

• # 🇯🇵 Yoshihito Nishioka

• # 🇺🇸 Tommy Paul

• # 🇺🇸 Tim Smyczek

• # 🇯🇵 Tatsuma Ito

Lucky losers
• # 🇧🇷 Rogério Dutra Silva

• # 🇺🇸 Jared Donaldson

• # 🇦🇷 Horacio Zeballos