2016 Mississippi Valley State Delta Devils football team

The 2016 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2016 NCAA Division I FCS football season. Led by third-year head coach Rick Comegy, the Delta Devils compiled an overall record of 1–10 and a mark of 1–8 in conference play, placing last out of five teams in the SWAC's East Division. Mississippi Valley State played home games at Rice–Totten Stadium in Itta Bena, Mississippi.