2016 Monterrey Challenger – Singles

Thiemo de Bakker was the defending champion but chose not to defend his title.

Ernesto Escobedo won the title after defeating Denis Kudla 6–4, 6–4 in the final.

Seeds
• # 🇩🇴 Víctor Estrella Burgos (second round)

• # 🇩🇪 Benjamin Becker (semifinals)

• # 🇺🇸 Denis Kudla (final)

• # 🇦🇷 Marco Trungelliti (second round)

• # 🇺🇸 Ernesto Escobedo (champion)

• # 🇨🇦 Peter Polansky (semifinals)

• # 🇨🇴 Eduardo Struvay (first round)

• # 🇨🇴 Alejandro González (first round)