2016 Morelos Open – Men's singles

Víctor Estrella Burgos was the defending champion, but withdrew from the tournament.

Gerald Melzer won the title, defeating Alejandro González in the final 7–6(7–4), 6–3.

Seeds
• # 🇩🇴 Víctor Estrella Burgos (withdrew)

• # 🇦🇷 Horacio Zeballos (semifinals)

• # 🇦🇹 Gerald Melzer (champion)

• # 🇨🇴 Alejandro González (final)

• # 🇪🇸 Adrián Menéndez-Maceiras (quarterfinals)

• # 🇺🇸 Alexander Sarkissian (quarterfinals)

• # 🇦🇹 Dennis Novak (first round)

• # 🇪🇸 Jordi Samper-Montaña (first round)

• # 🇪🇨 Giovanni Lapentti (first round)