2016 Mutua Madrid Open – Men's singles

Novak Djokovic defeated the defending champion Andy Murray in the final, 6–2, 3–6, 6–3, to win the men's singles tennis title at the 2016 Madrid Open. It was Djokovic's second title in Madrid and his record 29th ATP Masters 1000 title.

Seeds
The top eight seeds receive a bye into the second round. • 🇷🇸 Novak Djokovic (champion)

• 🇬🇧 Andy Murray (final)

• Roger Federer (withdrew due to back injury)

• Stan Wawrinka (second round)

• 🇪🇸 Rafael Nadal (semifinals)

• 🇯🇵 Kei Nishikori (semifinals)

• 🇫🇷 Jo-Wilfried Tsonga (third round)

• 🇨🇿 Tomáš Berdych (quarterfinals)

• 🇪🇸 David Ferrer (third round)

• 🇫🇷 Richard Gasquet (third round)

• 🇨🇦 Milos Raonic (quarterfinals)

• 🇧🇪 David Goffin (first round)

• 🇫🇷 Gaël Monfils (second round)

• 🇦🇹 Dominic Thiem (first round)

• 🇪🇸 Roberto Bautista Agut (third round)

• 🇫🇷 Gilles Simon (third round)

Seeds
• # 🇪🇸 Marcel Granollers (qualifying competition, lucky loser)

• # 🇫🇷 Lucas Pouille (qualified)

• # 🇪🇸 Íñigo Cervantes (first round)

• # 🇫🇷 Paul-Henri Mathieu (withdrew)

• # 🇺🇸 Denis Kudla (qualified)

• # Robin Haase (qualifying competition)

• # 🇷🇸 Dušan Lajović (qualifying competition)

• # 🇺🇸 Taylor Fritz (first round)

• # 🇺🇿 Denis Istomin (qualified)

• # 🇺🇸 Rajeev Ram (first round)

• # Ivan Dodig (first round)

• # 🇷🇺 Mikhail Youzhny (qualifying competition)

• # 🇫🇷 Adrian Mannarino (first round)

• # 🇩🇴 Víctor Estrella Burgos (first round)

Qualifiers
• # 🇨🇿 Radek Štěpánek

• # 🇫🇷 Lucas Pouille

• # 🇺🇿 Denis Istomin

• # 🇫🇷 Pierre-Hugues Herbert

• # 🇺🇸 Denis Kudla

• # 🇪🇸 Roberto Carballés Baena

• # 🇨🇴 Santiago Giraldo

Lucky loser
• # 🇪🇸 Marcel Granollers