2016 Oklahoma State Cowboys baseball team

The 2016 Oklahoma State Cowboys baseball team represents Oklahoma State University during the 2016 NCAA Division I baseball season. The Cowboys play their home games at Allie P. Reynolds Stadium as a member of the Big 12 Conference. They are led by head coach Josh Holliday, in his fourth season at Oklahoma State.

Previous season
The 2015 Oklahoma State Cowboys baseball team notched a 38–20 (14–8) regular season record and finished second in the Big 12 Conference standings. The Cowboys reached the 2015 Big 12 Conference baseball tournament championship game, where they fell to Texas. Oklahoma State received an at-large bid to the 2015 NCAA Division I baseball tournament and was selected as one of the sixteen Regional hosts. The Cowboys were eliminated from the NCAA tournament with losses to Arkansas and St. John's (NY).

Schedule and results
! style="background:#FF6600;color:white;"| Regular season (35–18)
 * - valign="top"

! style="background:#FF6600;color:white;"| Postseason

"" represents postseason seeding in the Big 12 Tournament or NCAA Regional, respectively.
 * Legend:      = Win       = Loss      Bold = Oklahoma State team member
 * "#" represents ranking. All rankings from Collegiate Baseball on the date of the contest.
 * "#" represents ranking. All rankings from Collegiate Baseball on the date of the contest.
 * "#" represents ranking. All rankings from Collegiate Baseball on the date of the contest.