2016 Open Città della Disfida – Singles

Aljaž Bedene was the defending champion but chose not to participate.

Elias Ymer won the title, defeating Adam Pavlásek 7–5, 6–4 in the final.

Seeds
• # 🇧🇷 Rogério Dutra Silva (quarterfinals)

• # 🇪🇸 Roberto Carballés Baena (second round)

• # 🇨🇿 Adam Pavlásek (final)

• # Gastão Elias (quarterfinals)

• # 🇸🇰 Andrej Martin (second round)

• # Igor Sijsling (first round)

• # 🇮🇹 Luca Vanni (first round)

• # 🇸🇪 Elias Ymer (champion)